Organ Culturing

Hundreds of deserving people on the tranplant list die from waiting for an organ transplant each year. Of those that actually end up getting a transplant only 15% of organ transplants are successful and most only last for 10 years without failure.

By using Bone Marrow stem cells or iPSCs made from patients' skin cells, working organs can be grown and produced by seeding a stripped organ scaffold or artificial scaffold made to replicate a real organ.

The organs are cultured in a two step process. First the scaffold is prepared and primed for new cell growth. This can be done by either using an aritifical scaffold or by chemically stripping a donor organ of its cells leaving only the collagen and connective tissue scaffold. Second the cells are applied to the scaffold. Scientists build tissue up by seeding the scaffold with a stem cell solution of appropriate stem cells needed to create the desired organ.

This process could be especially effective in the growth of a lung from a donor that died from smoking related causes. Even though the lung failed for the donor the lung could be stripped of everything especially the tar and other toxins that might have caused to lung to fail.A solution of stem cells would then be seeded on the remaining scaffold and a new lung could be grown.

As long as the physical shape and structue of the organ is intact, organs that have failed can be stripped and then used to regrow a new organ on any patient. Using a scaffold for the growth of the organ is crucial in providing stem cells with the information that they need to know to differentiate into the proper functional cells.

Cord-blood cells are a prime source for stem cells that are very adept at producing organs

Stem cells can differentiate with little to no chemical additions or gene insertion. The cells' DNA holds all of the instruction and directions they need to differentiate into the correct cells. The cells know exactly what their roles and functions are simply by assesing their surroundings. This amazing trait of stem cells can be used to design a more refined process to differentiate stem cells into organs through the skillful use of different Bio-Materials.